[Highland Park] holiday driving help!

Dear Neighbors, Having just moved here, I'm still not familiar with traffic patterns over the Thanksgiving weekend. Nevertheless I've promised to pick somebody up at the airport and then drive 300 miles East (to a destination directly off Route 80) on the day before Thanksgiving. Here's my question: the various online mapping programs suggest two alternate routes and I'm trying to decide which is fastest - Route 22 or Route 28? thanks - and thanks so much list managers for this invaluable list! -justine